HRID391595

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57657904

未命名化合物

结构：COC(=O)Cc1cccc(S(C)(=O)=NC(=O)c2cncc(Br)c2)c1

HCID57657931

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Cc1cccc(S(C)(=O)=NC(=O)c2cncc(C#Cc3cccc(NC(=O)c4cc(C)nn4C)c3)c2)c1

HCID57657926

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described in Example 460, methyl (3-{N-[(5-bromopyridin-3-yl)carbonyl]-S-methylsulfonimidoyl}phenyl)acetate (202 mg, 0.492 mmol) and N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide (153 mg, 0.64 mmol), were converted to the title compound as a light yellow solid foam (275 mg, 98%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0e0b99c3d076441f885ed4bac8624917
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08383825B2
来源说明: uspto-grants-2013_02

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([C:8]([N:10]=[S:11]([C:14]2[CH:15]=[C:16]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH:17]=[CH:18][CH:19]=2)([CH3:13])=[O:12])=[O:9])[CH:5]=[N:6][CH:7]=1.[C:25]([C:27]1[CH:28]=[C:29]([NH:33][C:34]([C:36]2[N:40]([CH3:41])[N:39]=[C:38]([CH3:42])[CH:37]=2)=[O:35])[CH:30]=[CH:31][CH:32]=1)#[CH:26]>>[CH3:41][N:40]1[C:36]([C:34]([NH:33][C:29]2[CH:28]=[C:27]([C:25]#[C:26][C:2]3[CH:3]=[C:4]([C:8]([N:10]=[S:11]([C:14]4[CH:15]=[C:16]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH:17]=[CH:18][CH:19]=4)([CH3:13])=[O:12])=[O:9])[CH:5]=[N:6][CH:7]=3)[CH:32]=[CH:31][CH:30]=2)=[O:35])=[CH:37][C:38]([CH3:42])=[N:39]1