HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 391614Generated: October 26, 2026
Imidazole → Methyl 4-(1H-imidazol-1-yl)benzoate
https://huagongshe.com/reaction/391614
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-fluorobenzoate | HCID 67878 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 4-(1H-imidazol-1-yl)benzoate | HCID 2766374 | 59% |
Reaction Steps
A mixture of imidazole (132 g, 1.9 mol), methyl 4-fluorobenzoate (170 ml, 1.3 mol) and potassium carbonate (357 g, 2.6 mol) in DMSO (200 ml) is stirred at 120° C. for 3 h. After cooling to room temperature, the mixture is added to ice-water. Precipitated product is filtered off and washed with water. Yield: 59%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08384068B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-d7c8b716636841a7987aa628054d3ab8 |
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| Source note | uspto-grants-2013_02 |
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