Potassium Phosphate, Tribasic → HCID 57474587, compound

Participants

Reaction Steps

5-Amino-6-tert-butylamino-2-(3-hydroxy-phenyl)-pyrimidine-4-carboxylate. In a microwave flask was placed 5-amino-6-tert-butylamino-2-chloro-pyrimidine-4-carboxylate (0.46 g, 1.69 mmol), 3-hydroxyphenylboronic acid (0.35 g, 2.53 mmol), potassium phosphate (0.72 g, 3.4 mmol), dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (0.10 g, 0.25 mmol) and palladium (II) acetate (0.06 g, 0.25 mmol) in tetrahydrofuran (17 mL) and water (1.7 mL). The mixture was reacted according to General Procedure E. The crude residue was purified using Biotage silica gel chromatography (0-35% ethyl acetate in hexanes) to afford the title compound (0.26 g, 0.79 mmol, 36% yield). MS (ESI) m/z 331.4 [M+1]+.

Provenance & Evidence