4-Formylbenzoic acid → HCID 24938105, compound

Participants

Reaction Steps

4-[6-Carbamoyl-9-(2-methoxy-phenyl)-8-oxo-8,9-dihydro-7H-purin-2-yl]-benzoic acid. (Z)-1-(2-Amino-1,2-dicyanovinyl)-3-(2-methoxyphenyl)urea (See Example 2.A) (0.30 g, 1.2 mmol), 4-formylbenzoic acid (0.44 g, 2.65 mmol) and triethylamine (3.0 mL) were reacted according to General Procedure B. The crude residue was purified using Biotage silica gel chromatography (0-100% ethyl acetate in hexanes) to afford the title compound in 99.4% purity (0.129 g, 0.069 mmol, 51% yield). 1H NMR (300 MHz, DMSO-d6) δ 11.85 (s, 1H), 8.56 (s, 1H), 8.48 (d, J=8.2, 1H), 8.03 (s, 1H), 7.99 (d, J=8.5, 1H), 7.49-7.61 (m, 1H), 7.31 (d, J=8.5, 1H), 7.17 (td, J=7.7, 1.1, 1H), 3.76 (s, 1H); MS (ESI) m/z 420.1 [M+1]+; mp 328-332° C.

Provenance & Evidence