Diisopropylethylamine → HCID 24936850, compound

Participants

Reaction Steps

Ethyl 2-chloro-6-((2-ethoxy-2-oxoethyl)(2-methoxyphenyl)amino)-5-nitro-5,6-dihydro-pyrimidine-4-carboxylate. Ethyl 2,6-dichloro-5-nitropyrimidine-4-carboxylate (3.0 g, 11.27 mmol), ethyl 2-(2-methoxyphenylamino)acetate (2.35 g, 11.27 mmol) and diisopropylethylamine (4.36 g, 33.81 mmol) were reacted according to General Procedure C and partitioned between water and ethyl acetate (3×) to afford the title compound without purification (2.05 g, 41%). MS (ESI) m/z 439.2 [M+1]+, 441.4 [M+2]+.

Provenance & Evidence