Ethanol → HCID 178489571, compound

Participants

Reaction Steps

Ethyl 5-amino-2-(trans-4-hydroxycyclohexylamino)-6-(2-methoxyphenylamino)pyrimidine-4-carboxylate. Ethyl 2-(trans-4-hydroxycyclohexylamino)-6-(2-methoxyphenyl-amino)-5-nitropyrimidine-4-carboxylate (0.300 g, 0.852 mmol) was dissolved in ethanol (20 mL) and 10% palladium on carbon (0.073 g) were added to the flask and flushed with fresh hydrogen gas and allowed to stir at room temperature. After 16 hours, the reaction was filtered through celite and the filtrate condensed under reduced pressure. The crude oil was purified using biotage chromatography (5% methanol in ethyl acetate) to afford the title compound (0.240 g, 70%). MS (ESI) m/z 402.4 [M+1]+.

Provenance & Evidence