HCID 57474771, compound → HCID 57474769, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 5-amino-6-(2,3-dihydro-1H-inden-1-ylamino)-2-(3-(triisopropylsilyloxy)phenyl)pyrimidine-4-carboxylate. Methyl 5-amino-2-chloro-6-(isobutylamino)pyrimidine-4-carboxylate. (0.285 g, 1.11 mmol) triisopropyl(3-(trimethylstannyl)phenoxy)silane (0.691 g, 1.67 mmol) and bisdichloro(triphenylphosphine) palladium (0) (0.311 g, 0.444 mmol) were combined in dimethyl formamide (4 mL) and heated to 100° C. The reaction was monitored via thin layer chromatography. Once starting materials were consumed, the solution was condensed under reduced pressure and purified using Biotage chromatography (0 to 40% EtOAc in hexanes) to afford the title compound (0.300 g, 58%). MS (ESI) m/z 473.6 [M+1]+.

Provenance & Evidence