反应详情

12.1 Parts of 2-amino-4-fluoro-6-fluoromethylpyrimidine was dissolved in 200 parts of 20% aqueous acetic acid at reflux, with stirring. The mixture was heated under reflux for 1 hour then cooled. The precipitated solid was filtered, washed with 50% aqueous acetic acid and then with acetone. The solid was dried in vacuo at 140° C. to give 2-amino-6-fluoromethylpyrimidine-4-one, m.p. 237°-238° C. (decomposition).

1. temperatureat reflux
2. temperatureThe mixture was heated
3. temperatureunder reflux for 1 hour
4. temperaturethen cooled
5. filtrationThe precipitated solid was filtered
6. washwashed with 50% aqueous acetic acid
7. customThe solid was dried in vacuo at 140° C.