HCID 57474804, compound → HCID 57474812, compound

Participants

Reaction Steps

Methyl 2-(3-(tert-butyldiphenylsilyloxy)phenyl)-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purine-6-carboxylate. Methyl 5-amino-2-(3-(tert-butyldiphenylsilyloxy)phenyl)-6-(tetrahydro-2H-pyran-4-ylamino)pyrimidine-4-carboxylate (0.361 g, 0.722 mmol) and 1,1′-1,1′-carbonyldiimidazole (0.702 g, 4.33 mmol) in dichloromethane (15 mL) were reacted according to General Procedure F and purified via biotage chromatography (0 to 75% EtOAc in hexanes) to afford the title compound (0.270 g, 71%). 1H NMR (400 MHz, DMSO-d6) δ 11.80 (s, 1H), 7.96 (s, 2H), 7.41 (t, J=8.39, 1H), 7.00 (dd, J=7.99 2.39, 1H), 4.51 (m, 1H), 4.01 (dd, J=11.19, 3.59, 2H), 3.94 (s, 3H), 3.48 (t, J=11.99, 2H), 2.65 (m, 2H), 1.75 (d, 9.59, 2H), 1.33 (m, 3H), 1.10 (d, J=3.59, 18H).

Provenance & Evidence