Ammonia → HCID 178513786, compound

Participants

Reaction Steps

tert-Butyl trans-4-(6-carbamoyl-2-(3-hydroxyphenyl)-8-oxo-7H-purin-9(8H)-yl)cyclohexylcarbamate. Ethyl 9-(trans-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate (0.070 g, 0.140 mmol) and ammonia in methanol were reacted according to General Procedure G. After 16 h, LCMS confirms product and the solution was condensed under reduced pressure to afford the title compound (0.040 g, 60%). MS (ESI) m/z 469 [M+1]+.

Provenance & Evidence