Tetrahydrofuran → HCID 66647793, compound

Participants

Reaction Steps

(S,Z)-1-(2-Amino-1,2-dicyanovinyl)-3-(tetrahydrofuran-3-yl)urea. (S)-3-Isocyanato tetrahydrofuran toluene sulfonate salt (0.825 g, 7.29 mmol) and diaminomaleonitrile (1.57 g, 14.59 mmol) were reacted according to General Procedure A in tetrahydrofuran (10 mL) and purified via reverse-phase preparative HPLC (0-10% acetonitrile+0.1% TFA in H2O+0.1% TFA, over 35 min) to afford the title compound (0.636, 39%). MS (ESI) m/z 222.2 [M+1]+.

Provenance & Evidence