HCID 86654925, compound → HCID 86654924, compound
Reaction equation
C[O:2][C:3](=[O:67])[C@:4]([NH:21][C:22]([CH:24]1[CH2:33][C:32]2[CH:31]=[C:30]3[O:34][CH2:35][C@H:36]([C:38]4[CH:43]=[CH:42][C:41]([O:44][CH2:45][C:46]5[CH:51]=[CH:50][C:49]([Cl:52])=[C:48]([Cl:53])[CH:47]=5)=[CH:40][CH:39]=4)[O:37][C:29]3=[CH:28][C:27]=2[CH2:26][N:25]1[S:54]([C:57]1[S:61][C:60]([NH:62]C(=O)C)=[N:59][C:58]=1[CH3:66])(=[O:56])=[O:55])=[O:23])([CH3:20])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.COC(=O)[C@](NC(C1CC2C=C3OC[C@H](C4C=CC(OCC5C=CC(Cl)=C(Cl)C=5)=CC=4)OC3=CC=2CN1S(C1SC(N)=NC=1C)(=O)=O)=O)(C)CC1C=CC(C2C=CC(C#N)=CC=2)=CC=1>>[NH2:62][C:60]1[S:61][C:57]([S:54]([N:25]2[CH:24]([C:22]([NH:21][C@@:4]([CH3:20])([CH2:5][C:6]3[CH:7]=[CH:8][C:9]([C:12]4[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=4)=[CH:10][CH:11]=3)[C:3]([OH:67])=[O:2])=[O:23])[CH2:33][C:32]3[CH:31]=[C:30]4[O:34][CH2:35][C@H:36]([C:38]5[CH:43]=[CH:42][C:41]([O:44][CH2:45][C:46]6[CH:51]=[CH:50][C:49]([Cl:52])=[C:48]([Cl:53])[CH:47]=6)=[CH:40][CH:39]=5)[O:37][C:29]4=[CH:28][C:27]=3[CH2:26]2)(=[O:56])=[O:55])=[C:58]([CH3:66])[N:59]=1Participants
3
Procedure
(S)-2-({(S)-7-(2-acetylamino-4-methyl-thiazole-5-sulfonyl)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl}-amino)-3-(4′-cyano-biphenyl-4-yl)-2-methyl-propionic acid methyl ester was converted to (S)-2-({(S)-7-(2-amino-4-methyl-thiazole-5-sulfonyl)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2,3,6,7,8,9-hexahydro-[1,4]-dioxino[2,3-g]isoquinoline-8-carbonyl}-amino)-3-(4′-cyano-biphenyl-4-yl)-2-methyl-propionic acid methyl ester according to General Procedure N. This ester, upon hydrolysis according to General Procedure B, gave the title compound. LCMS (m/z): 927.
Sources & evidence
- ORD record
- ord-4dc56587a3934759a47984ccf521b759
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08383644B2
Reaction notes
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