HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylsulphamoyl chloride → HCID 58327411, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylsulphamoyl chloride | HCID 83372 | — |
| Edukt | (S)-2-({(3S,8S)-3-[4-(3,4-Dichloro-benzyloxy)-phenyl]-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl}-amino)-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester dihydrochloride | HCID 66719474 | — |
| Produkt | HCID 58327411 | HCID 58327411 | — |
Reaktionsschritte
(S)-2-({(3S,8S)-3-[4-(3,4-Dichloro-benzyloxy)-phenyl]-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl}-amino)-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester bis hydrochloride was coupled with N,N-dimethylsulfamoyl chloride according to General Procedure E. The resulting compound was hydrolyzed according to General Procedure B to give the title compound (9 mg). LCMS (m/z) 862.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08383644B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-cac5246713134fe69ba9ce6789be7917 |
| Quellennotiz | uspto-grants-2013_02 |