1,2-Dichloroethane → HCID 23521315, compound

Participants

Reaction Steps

To a stirred mixture of [3S/R, (2S)]-5-fluoro-4-oxo-3-{[1-(phenothiazine-10-carbonyl)piperidine-2-carbonyl]amino}-pentanoic acid (196 mg, 0.4 mmol), prepared as in Example 1, in anhydrous DCM (8 ml), was added Polymer bound EDC (400 mg, 0.8 mmol) and a solution of the ethylamine in THF (0.6 ml of a 2M solution, 12 mmol). The mixture was stirred at room temperature for 16 h then concentrated under reduced pressure. The residue was purified by flash chromatography (2.5% methanol in dichloromethane) to afford the title compound as a white solid (22.7 mg, 11%): 1H NMR (400 MHz, CDCl3) δ 1.09-1.39 (3H, m), 1.44-1.66 (6H, m), 2.04-3.66 (7H, m), 4.18-4.76 (6H, m) and 7.10-7.79 (8H, m). 19F NMR (376 MHz, CDC3) δ −223.32, −223.73, −225.92 and −226.76.

Provenance & Evidence