Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | CID 19593658 | HCID 19593658 | — |
| Reactant | HCID 22662723 | HCID 22662723 | — |
| Solvent | Methanesulfonic Acid | HCID 6395 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 22662729 | HCID 22662729 | — |
Reaction Steps
0.37 g of 5-fluoro-benzo[b]thiophene-3-sulphonic acid-methylamide are dissolved in 5.9 ml of methanesulphonic acid at 35° C. and combined with a solution of 0.06 g of trioxane in 1.8 ml of trifluoroacetic acid. After 2.5 h stirring at 35° C. the reaction mixture is poured onto 100 ml of ice water and the aqueous phase is extracted with ethyl acetate. The combined organic extracts are dried with Na2SO4, evaporated down in vacuo and then purified by chromatography. Yield: 0.22 g. M.p.: 175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06800623B2 |
|---|
| Source dataset | uspto-grants-2004_10 |
|---|
| ORD ID | ord-47021c6f9c94476882788b64e6220078 |
|---|
| Source note | uspto-grants-2004_10 |
|---|
