HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 392063Generated: October 30, 2026
Triethylamine → 1,3-dihydro-1-[2-[4-(hydroxymethyl)-1-piperidinyl]ethyl]-3-(1-methylethyl)-2H-imidazol-2-one
https://huagongshe.com/reaction/392063
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(2-chloroethyl)-1,3-dihydro-3-(1-methylethyl)-2H-imidazol-2-one | HCID 22662762 | — |
| Reactant | (Piperidin-4-yl)methanol--hydrogen chloride (1/1) | HCID 24191744 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1,3-dihydro-1-[2-[4-(hydroxymethyl)-1-piperidinyl]ethyl]-3-(1-methylethyl)-2H-imidazol-2-one | HCID 22662764 | 43% |
Reaction Steps
A mixture of 1-(2-chloroethyl)-1,3-dihydro-3-(1-methylethyl)-2H-imidazol-2-one (12 g), 4-piperidinemethanol hydrochloride (9.1 g), N,N-diethylethanamine (21 ml) and KI (catalytic amount) in DMF (200 ml) was stirred for 20 hours at 70° C. The reaction mixture was cooled and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/(CH3OH/NH3) 95/5). The pure fractions were collected and the solvent was evaporated, yielding 6.9 g (43%) 1,3-dihydro-1-[2-[4-(hydroxymethyl)-1-piperidinyl]ethyl]-3-(1-methylethyl)-2H-imidazol-2-one (intermediate 3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06800628B2 |
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| Source dataset | uspto-grants-2004_10 |
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| ORD ID | ord-11dca14c1e234c3a89cda8e68c94f30f |
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| Source note | uspto-grants-2004_10 |
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