HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Amino-6-chloro-1,3-benzodioxole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Methyl 7-(acetylamino)-6-chloro-1,3-benzodioxole-4-carboxylate | HCID 22662759 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Amino-6-chloro-1,3-benzodioxole-4-carboxylic acid | HCID 22662747 | 96.9% |
Reaction Steps
Intermediate 21 (18.2 g) was added to a solution of KOH (37.6 g) in water (380 ml). The resulting reaction mixture was stirred and refluxed for 3 hours. The mixture was cooled, acidified with hydrochloric acid, and the resulting precipitate was filtered off, washed with water, suspended in ACN, filtered off, then dried, yielding 14 g (>95%) of 7-amino-6-chloro-1,3-benzodioxole-4-carboxylic acid (intermediate 22).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06800628B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-37c6beee122040d19ddf515c957a88ca |
| Source note | uspto-grants-2004_10 |