Sulfuric Acid → HCID 86639892, compound

HRID 39209Notes

Reaction equation

HRID 39209 reaction equation
[CH3:1][N:2]([CH3:11])[C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][C:5]([OH:7])=[O:6].[S:12](=[O:16])(=[O:15])([OH:14])[OH:13]>O>[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].[CH3:11][N:2]([CH3:1])[C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 12774059Dimethyl aspartic acid

Product 1

HCID 86639892HCID 86639892, compoundYield 95.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 g of dimethylaspartic acid was placed in a 250 ml round-bottom flask, and 40 ml of water was added and stirred for 30 minutes. Then, 7.36 g of concentrated sulfuric acid (concentration: 98%) was slowly added to the flask. After the addition, a reaction was conducted for 2 hours. The reaction solution was concentrated, and azeotroped with 100 ml of toluene to further remove the water. Afterwards, the product was dried under high vacuum, and ground by using a spatula to obtain 15.34 g of N,N-dimethylaspartic acid sulfate as tawny oil (Yield: 95.33%).

Workup

  1. additionAfter the addition
  2. waita reaction was conducted for 2 hours
  3. concentrationThe reaction solution was concentrated
  4. customazeotroped with 100 ml of toluene
  5. customto further remove the water
  6. customAfterwards, the product was dried under high vacuum, and ground

Sources & evidence

ORD record
ord-1b3390e9bfa64341bea863de1043ac68
Source dataset
uspto-grants-2013_09
Patent number
US08524895B2

Reaction notes

Loading…