2,6-Diamino-N2-(2-aminoethyl)-5-nitropyridine → Tert-butyl 2-({2-[(6-amino-5-nitro(2-pyridyl))amino]-ethyl}amino)-4-(2,4-dichlorophenyl)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate

HRID 392100Notes

Reaction equation

HRID 392100 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10]2[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:20][CH2:19][C:11]=2[N:12]=[C:13](S(C)(=O)=O)[N:14]=1.[NH2:30][C:31]1[C:36]([N+:37]([O-:39])=[O:38])=[CH:35][CH:34]=[C:33]([NH:40][CH2:41][CH2:42][NH2:43])[N:32]=1>>[NH2:30][C:31]1[N:32]=[C:33]([NH:40][CH2:41][CH2:42][NH:43][C:13]2[N:14]=[C:9]([C:3]3[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])[C:10]3[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:20][CH2:19][C:11]=3[N:12]=2)[CH:34]=[CH:35][C:36]=1[N+:37]([O-:39])=[O:38]

Participants

3

Reactant 2

HCID 221423802,6-Diamino-N2-(2-aminoethyl)-5-nitropyridineHCID 69709898Tert-butyl 4-(2,4-dichlorophenyl)-2-(methylsulfonyl)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate

Product 1

HCID 57425229Tert-butyl 2-({2-[(6-amino-5-nitro(2-pyridyl))amino]-ethyl}amino)-4-(2,4-dichlorophenyl)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate

Procedure

Reaction of tert-butyl 4-(2,4-dichlorophenyl)-2-(methylsulfonyl)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate and 2-amino-3-nitro-6-(2-aminoethylamino)pyridine gave tert-butyl 2-({2-[(6-amino-5-nitro(2-pyridyl))amino]-ethyl}amino)-4-(2,4-dichlorophenyl)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate.

Sources & evidence

ORD record
ord-dedb60e3193e4c64a665a2bf8cc66fbe
Source dataset
uspto-grants-2004_10
Patent number
US06800632B2

Reaction notes

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