2,6-Diamino-N2-(2-aminoethyl)-5-nitropyridine → HCID 69762566, compound

HRID 392103Notes

Reaction equation

[Cl:1][C:2]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:3]=1[O:4][C:5]1[C:6]2[CH2:18][N:17]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:16][CH2:15][C:7]=2[N:8]=[C:9](S(C)(=O)=O)[N:10]=1.[NH2:31][C:32]1[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][CH:35]=[C:34]([NH:41][CH2:42][CH2:43][NH2:44])[N:33]=1>>[NH2:31][C:32]1[N:33]=[C:34]([NH:41][CH2:42][CH2:43][NH:44][C:9]2[N:10]=[C:5]([O:4][C:3]3[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:2]=3[Cl:1])[C:6]3[CH2:18][N:17]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:16][CH2:15][C:7]=3[N:8]=2)[CH:35]=[CH:36][C:37]=1[N+:38]([O-:40])=[O:39]

Participants

Reactant 2

HCID 221423802,6-Diamino-N2-(2-aminoethyl)-5-nitropyridine

HCID 69710279HCID 69710279, compound

Product 1

HCID 69762566HCID 69762566, compound

Procedure

Following Example 7, treatment of tert-butyl 4-(2,4-dichlorophenoxy)-2-(methylsulfonyl)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate with 2-amino-3-nitro-6-(2-aminoethylamino)pyridine gave tert-butyl 2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenoxy)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate.

Sources & evidence

ORD record: ord-9ca51eafca3d45e68e69dbe2d0475a3c
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06800632B2

Reaction notes

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