2,6-Diamino-N2-(2-aminoethyl)-5-nitropyridine → HCID 57425231, compound

HRID 392105Notes

Reaction equation

HRID 392105 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:11]2[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:21][CH2:20][C:12]=2[N:13]=[C:14](S(C)(=O)=O)[N:15]=1.[NH2:31][C:32]1[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][CH:35]=[C:34]([NH:41][CH2:42][CH2:43][NH2:44])[N:33]=1>>[NH2:31][C:32]1[N:33]=[C:34]([NH:41][CH2:42][CH2:43][NH:44][C:14]2[N:15]=[C:10]([NH:9][C:3]3[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])[C:11]3[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:21][CH2:20][C:12]=3[N:13]=2)[CH:35]=[CH:36][C:37]=1[N+:38]([O-:40])=[O:39]

Participants

3

Reactant 2

HCID 221423802,6-Diamino-N2-(2-aminoethyl)-5-nitropyridineHCID 69709509HCID 69709509, compound

Product 1

HCID 57425231HCID 57425231, compound

Procedure

Following Example 7, treatment of tert-butyl 4-[(2,4-dichlorophenyl)amino]-2-(methylsulfonyl)-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate with 2-amino-3-nitro-6-(2-aminoethylamino)pyridine gave tert-butyl 2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-[(2,4-dichlorophenyl)amino]-5,6,7,8-tetrahydropyridino[4,3-d]pyrimidine-6-carboxylate.

Sources & evidence

ORD record
ord-2300261b2c4d444a9c2d570ec202ce97
Source dataset
uspto-grants-2004_10
Patent number
US06800632B2

Reaction notes

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