HCID 86591423, compound → HCID 9947960, compound

HRID 392109Notes

Reaction equation

HRID 392109 reaction equation
C([O:8][NH:9][C:10](=[O:28])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:27][CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19]1)C1C=CC=CC=1>CO.[Pd]>[OH:8][NH:9][C:10](=[O:28])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:27][CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19]1

Participants

4

Reactant 1

HCID 86591423HCID 86591423, compound

Product 1

HCID 9947960HCID 9947960, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

200 mg (0.53 mmol) 8-(3,4-dihydro-1H-isoquinolin-2-yl)-octanoic acid benzyloxy-amide in 30 ml methanol was hydrogenated for 1 h in the presence of palladium on barium sulfate at ambient temperature and pressure. The catalyst was removed by filtration and the solvent was evaporated. There was thus obtained 150 mg (98%) 8-(3,4-dihydro-1H-isoquinolin-2-yl)-octanoic acid hydroxyamide as an amorphous solid. MS: 291 (M+H+).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-52ddcddd69014057a8be0467b3215477
Source dataset
uspto-grants-2004_10
Patent number
US06800638B2

Reaction notes

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