反应详情

10.7 g of N-methylaspartic acid was placed in a 250 ml round-bottom flask, and 100 ml of water was added to the flask and stirred for 30 minutes by using a magnetic stirrer. 7.12 g of concentrate sulfuric acid (concentration: 98%) was slowly dropped into the flask under stirring, and stirred for additional 2 hours after dropping. After the reaction, the reaction solution was concentrated, azeotroped with 100 ml of toluene to further remove the water and dried under vacuum to obtain 17 g of N-methylaspartic acid sulfate as yellow oil (Yield: 95.3%).

1. stirringunder stirring
2. stirringstirred for additional 2 hours
3. customAfter the reaction
4. concentrationthe reaction solution was concentrated
5. customazeotroped with 100 ml of toluene
6. customto further remove the water
7. customdried under vacuum