Sulfuric Acid → HCID 86639895, compound

HRID 39212Notes

Reaction equation

HRID 39212 reaction equation
[CH3:1][N:2]([CH3:12])[C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][C:6]([OH:8])=[O:7].[S:13](=[O:17])(=[O:16])([OH:15])[OH:14]>O>[S:13]([OH:17])([OH:16])(=[O:15])=[O:14].[CH3:12][N:2]([CH3:1])[C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 12021025Dimethyl glutamic acid

Product 1

HCID 86639895HCID 86639895, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.9 g of dimethylglutamic acid was placed in a 100 ml round-bottom flask, and 40 ml of water was added and stirred for 30 minutes. Then, 2.98 g of concentrated sulfuric acid (concentration: 98%) was slowly added to the flask. After the addition, a reaction was conducted for 2 hours. The reaction solution was concentrated, and azeotroped with 100 ml of toluene to further remove the water. Afterwards, the product was dried under high vacuum to obtain 7.6 g of N,N-dimethylglutamic acid sulfate as tawny oil (Yield: 96.32%).

Workup

  1. additionAfter the addition
  2. waita reaction was conducted for 2 hours
  3. concentrationThe reaction solution was concentrated
  4. customazeotroped with 100 ml of toluene
  5. customto further remove the water
  6. customAfterwards, the product was dried under high vacuum

Sources & evidence

ORD record
ord-7b6ccd7a1f3c4ad4b54de45712b800ce
Source dataset
uspto-grants-2013_09
Patent number
US08524895B2

Reaction notes

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