反应详情

4.9 g of dimethylglutamic acid was placed in a 100 ml round-bottom flask, and 40 ml of water was added and stirred for 30 minutes. Then, 2.98 g of concentrated sulfuric acid (concentration: 98%) was slowly added to the flask. After the addition, a reaction was conducted for 2 hours. The reaction solution was concentrated, and azeotroped with 100 ml of toluene to further remove the water. Afterwards, the product was dried under high vacuum to obtain 7.6 g of N,N-dimethylglutamic acid sulfate as tawny oil (Yield: 96.32%).

1. additionAfter the addition
2. waita reaction was conducted for 2 hours
3. concentrationThe reaction solution was concentrated
4. customazeotroped with 100 ml of toluene
5. customto further remove the water
6. customAfterwards, the product was dried under high vacuum