HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 392131Generated: October 30, 2026
Aluminium lithium hydride → 2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethanamine
https://huagongshe.com/reaction/392131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 2-Oxo-2-(1H-pyrrolo[3,2-C]pyridin-3-YL)-acetamide | HCID 22663037 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethanamine | HCID 22662986 | — |
Reaction Steps
A solution of 2-oxo-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)-acetamide (1 eq.) in ether is treated with lithium aluminum hydride (4 eq.), refluxed for 8 h, cooled to 0° C. and quenched by addition of Rochelle's salt solution. The reaction mixture is extracted with CH2Cl2. The extracts are combined dried over MgSO4 and concentrated in vacuo to give the title amine product, which is used as is in step 9, below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06800640B2 |
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| Source dataset | uspto-grants-2004_10 |
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| ORD ID | ord-4ba790d610434beab5e0e9576e34936c |
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| Source note | uspto-grants-2004_10 |
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