反应详情

温度

0 °C

A solution of 2-oxo-2-(1H-pyrrolo[2,3-c]pyridin-3-yl)acetamide (1 eq.) in ether is treated with lithium aluminum hydride (4 eq.), heated at reflux temperature for 8 h, cooled to 0° C. and quenched by addition of Rochelle's salt solution. The reaction mixture is extracted with CH2Cl2; the combined extracts are dried over MgSO4 and concentrated in vacuo to afford the title 6-azatryptamine product, which is used directly in step 4, below.

1. temperatureheated
2. temperatureat reflux temperature for 8 h
3. customquenched by addition of Rochelle's salt solution
4. extractionThe reaction mixture is extracted with CH2Cl2
5. dry with materialthe combined extracts are dried over MgSO4
6. concentrationconcentrated in vacuo