反应详情

This compound was prepared by the same method as for intermediate 25, using 4.15 g (21.6 mmol) of 2-(7-methoxybenzofuran-3-yl)-ethanol, 6.8 g (25.9 mmol) of triphenylphosphine, 1.34 mL (25.9 mmol) of bromine, and 3.5 mL (43.2 mmol) of pyridine in 70 mL of CH2Cl2, to afford 2.87 g (52%) of the title compound after flash chromatography on SiO2 (25% CH2Cl2/hexanes to 100% CH2Cl2 gradient): MS (ESI) m/z 254 [M]+.