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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 392176Generated: October 29, 2026

p-Methylthiophenylboric acid → 6,7-Dimethoxy-2-methylamino-4-[5-(4-methylthiophenyl)-3-pyridyl]quinazoline

https://huagongshe.com/reaction/392176

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Methylthiophenylboric acidHCID 21939890—
ReactantHCID 22663121HCID 22663121—
Product6,7-Dimethoxy-2-methylamino-4-[5-(4-methylthiophenyl)-3-pyridyl]quinazolineHCID 22950994105.2%

Reaction Steps

Starting from 375 mg of 4-(5-bromo-3pyridyl)-6,7-dimethoxy-2-methylaminoquinazoline obtained in Example 76 and 225 mg of 4-methylthiophenylboric acid, 440 mg of the title compound was obtained as pale yellow crystals in the same manner as in Example 48.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06800644B2
Source datasetuspto-grants-2004_10
ORD IDord-7a141fb838aa43c9bd25cb7f68dc84e6
Source noteuspto-grants-2004_10