反应详情

温度

60 °C

To a solution of 2-amino-4-trifluoromethylthiophenol hydrochloride (30.0 g) in ethanol (125 ml) was added 2-chloro-1,1,1-triethoxyethane (31.0 g). The mixture was heated for 1 hour at 60° C. The solution was concentrated to remove excess ethanol and the resulting material was extracted with ether (500 ml). The organic extract was washed successively with 10% HCl (20 ml), water (100 ml), 10% sodium bicarbonate solution and water (100 ml), and then evaporated to obtain an amber colored oil, which crystallized upon standing at room temperature (28.9 g; m.p. 52° C).

1. concentrationThe solution was concentrated
2. customto remove excess ethanol
3. extractionthe resulting material was extracted with ether (500 ml)
4. extractionThe organic extract
5. washwas washed successively with 10% HCl (20 ml), water (100 ml), 10% sodium bicarbonate solution and water (100 ml)
6. customevaporated
7. customto obtain an amber colored oil, which
8. customcrystallized
9. customupon standing at room temperature