HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidine → 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidine | HCID 10444 | — |
| Reactant | 2-Cyano-3-difluoromethoxyphenylsulfonyl chloride | HCID 58100767 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile | HCID 44199441 | — |
Reaction Steps
54 mg of 2-cyano-3-difluoromethoxy-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 32 I of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by HPLC affords 35 mg of 2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524896B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-4e03c46cba5d4544802825dfbdd6204e |
| Source note | uspto-grants-2013_09 |