HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidine → 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidine | HCID 10444 | — |
| Reactant | 2-Cyano-3-fluorobenzene-1-sulfonyl chloride | HCID 20505212 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile | HCID 44218655 | — |
Reaction Steps
440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524896B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-62d17e228e394a5fafc800d9e62ffeab |
| Source note | uspto-grants-2013_09 |