Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 6-Chloro-2-chloromethyl-3-(2-chlorophenyl)-3H-quinazolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 2-Amino-5-chloro-N-(2-chlorophenyl)benzamide | HCID 16781782 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 6-Chloro-2-chloromethyl-3-(2-chlorophenyl)-3H-quinazolin-4-one | HCID 22316565 | 92% |
반응 단계
Prepared according to Procedure B with 1d (500 mg, 1.78 mmol) and chloroacetyl chloride (0.42 mL, 5.33 mmol) in acetic acid (10 mL). Purified by recrystallization from isopropanol to afford 555 mg of a yellow solid (92%). 1H NMR (CDCl3) δ: 8.27 (d, J=1.9 Hz, 1H); 7.74-7.78 (m, 2H); 7.60-7.66 (m, 1H); 7.48-7.57 (m, 3H); 4.37 (d, J=12 Hz, 1H), 4.07 (d, J=12 Hz, 1H). MS (ES): m/z 339.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06800620B2 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-bb7804bba0ce49ab918a842af4422ca3 |
| 출처 메모 | uspto-grants-2004_10 |