HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Fluoro-6-(3-oxo-pyrrolidine-1-sulfonyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyrrolidin-3-one hydrochloride | HCID 19106857 | — |
| Reactant | 2-Cyano-3-fluorobenzene-1-sulfonyl chloride | HCID 20505212 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Fluoro-6-(3-oxo-pyrrolidine-1-sulfonyl)-benzonitrile | HCID 44218661 | 15.6% |
Reaction Steps
110 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 5 ml of tetrahydrofuran are treated with 61 mg of 3-oxo-pyrrolidine hydrochloride and with 0.14 ml of triethylamine, and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo, the residue is solved in ethyl acetate and washed with a 1M HCl solution. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) affords 21 mg of 2-fluoro-6-(3-oxo-pyrrolidine-1-sulfonyl)-benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524896B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-e2d1cdd8e0cb493a929b383643dbff70 |
| Source note | uspto-grants-2013_09 |