Hydrochloric Acid → HCID 59079565, compound

Participants

Reaction Steps

In 2 ml of methanol was dissolved 0.20 g of {(2R,3S)-3-(acetyloxy)-5-[3-(aminocarbonyl)-2-oxo-1(2H)-pyrazinyl]tetrahydro-2-furanyl}methyl acetate. While cooling the solution with ice, 0.23 g of 28% methanol solution of sodium methoxide was added, and stirred for 20 minutes. Then, 1.2 ml of 1 mol/L hydrochloric acid was added to the reaction mixture, and the solvent was removed under reduced pressure. The residue thus obtained was purified by column chromatography [eluent: chloroform:methanol=10:1] to obtain 90 mg of 4-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-3-oxo-3,4-dihydro-2-pyrazinecarboxamide as a yellow oily product.

Provenance & Evidence