反应详情

In 1 ml of methanol was dissolved 75 mg of methyl 4-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-3-oxo-3,4-dihydro-2-pyrazinecarboxylate. At room temperature, 25% aqueous solution of ammonia was added and stirred for 13 hours, and then the solvent was removed under reduced pressure. Isopropanol was added to the residue, and the solid product was collected by filtration to obtain 20 mg of 4-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-3-oxo-3,4-dihydro-2-pyrazinecarboxamide as a white-colored solid product.

1. customthe solvent was removed under reduced pressure
2. additionIsopropanol was added to the residue
3. filtrationthe solid product was collected by filtration