Ammonia → HCID 22662855, compound

HRID 392317Notes

Reaction equation

HRID 392317 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:7][CH:6]([N:8]2[CH:13]=[CH:12][N:11]=[C:10]([C:14](OC)=[O:15])[C:9]2=[O:18])[CH:5]=[CH:4]1.[NH3:19]>CO>[OH:1][CH2:2][CH:3]1[CH2:7][CH:6]([N:8]2[CH:13]=[CH:12][N:11]=[C:10]([C:14]([NH2:19])=[O:15])[C:9]2=[O:18])[CH:5]=[CH:4]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22662818Methyl 4-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-3-oxo-3,4-dihydro-2-pyrazinecarboxylate

Product 1

HCID 22662855HCID 22662855, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 1 ml of methanol was dissolved 75 mg of methyl 4-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-3-oxo-3,4-dihydro-2-pyrazinecarboxylate. At room temperature, 25% aqueous solution of ammonia was added and stirred for 13 hours, and then the solvent was removed under reduced pressure. Isopropanol was added to the residue, and the solid product was collected by filtration to obtain 20 mg of 4-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-3-oxo-3,4-dihydro-2-pyrazinecarboxamide as a white-colored solid product.

Workup

  1. customthe solvent was removed under reduced pressure
  2. additionIsopropanol was added to the residue
  3. filtrationthe solid product was collected by filtration

Sources & evidence

ORD record
ord-b5b502a5ffc94cdc9d8a88a11c1788b7
Source dataset
uspto-grants-2004_10
Patent number
US06800629B2

Reaction notes

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