Hydrochloric Acid → HCID 69760149, compound

Participants

Reaction Steps

In a mixture of 2 mL of tetrahydrofuran and 1 mL of water was dissolved 100 mg of {(3aR,4R,6R,6aR)-6-[3-(aminocarbonyl)-2-oxo-1(2H)-pyrazinyl]-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl dibenzyl phosphate. After adjusting the pH value to 0.5 with 6 mol/L hydrochloric acid, the mixture was left to stand at room temperature for 2 days. The deposited solid matter was collected by filtration and washed with ethanol to obtain 40 mg of {(2R,3S,4R,5R)-5-[3-(aminocarbonyl)-2-oxo-1(2H)-pyrazinyl]-3,4-dihydroxytetrahydro-2-furanyl}methyl dibenzyl phosphate as a solid product.

Provenance & Evidence