反应详情

In 5 mL of toluene was dissolved 1.0 g of 3-(allyloxy)-6-fluoro-2-pyrazinecarbonitrile. After adding 0.82 g of aluminum chloride, the mixture was stirred at room temperature for 1.5 hours. Water (5 mL) was added to the reaction mixture, the aqueous layer was separated, and the organic layer was extracted first with 3 mL of water and then with 2 ml of water. The aqueous layers were united and washed with 5 mL of toluene, and extracted with 15 mL of ethyl acetate. The organic layer thus obtained was washed with 3 mL of water and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. Thus, 0.45 g of 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile was obtained as a yellow-colored solid product.

1. customthe aqueous layer was separated
2. extractionthe organic layer was extracted first with 3 mL of water
3. washwashed with 5 mL of toluene
4. extractionextracted with 15 mL of ethyl acetate
5. customThe organic layer thus obtained
6. washwas washed with 3 mL of water
7. dry with materialdried on anhydrous magnesium sulfate
8. customthe solvent was removed under reduced pressure