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In a mixture of 1.5 mL of 25% aqueous ammonia and 500 mL of dioxane was dissolved 1.0 g of 3,6-difluoro-2-pyrazinecarbonitrile. The solution thus obtained was stirred at room temperature for 6 hours. Then, 20 mL of water was added to the reaction mixture and stirred for 20 minutes while cooling the mixture with ice. The deposited material was collected by filtration, washed successively with 5 mL of cold water and 5 mL of ethanol to obtain 0.84 g of 3-amino-6-fluoro-2-pyrazine-carbonitrile as a light yellow-colored solid product.

1. customThe solution thus obtained
2. stirringstirred for 20 minutes
3. temperaturewhile cooling the mixture with ice
4. filtrationThe deposited material was collected by filtration
5. washwashed successively with 5 mL of cold water and 5 mL of ethanol