Ammonia → HCID 22662784, compound

HRID 392346Notes

Reaction equation

HRID 392346 reaction equation
F[C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([F:8])=[CH:6][N:7]=1.O.[NH3:12]>O1CCOCC1>[NH2:12][C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([F:8])=[CH:6][N:7]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 226628293,6-Difluoropyrazine-2-carbonitrile

Product 1

HCID 22662784HCID 22662784, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a mixture of 1.5 mL of 25% aqueous ammonia and 500 mL of dioxane was dissolved 1.0 g of 3,6-difluoro-2-pyrazinecarbonitrile. The solution thus obtained was stirred at room temperature for 6 hours. Then, 20 mL of water was added to the reaction mixture and stirred for 20 minutes while cooling the mixture with ice. The deposited material was collected by filtration, washed successively with 5 mL of cold water and 5 mL of ethanol to obtain 0.84 g of 3-amino-6-fluoro-2-pyrazine-carbonitrile as a light yellow-colored solid product.

Workup

  1. customThe solution thus obtained
  2. stirringstirred for 20 minutes
  3. temperaturewhile cooling the mixture with ice
  4. filtrationThe deposited material was collected by filtration
  5. washwashed successively with 5 mL of cold water and 5 mL of ethanol

Sources & evidence

ORD record
ord-b5ea4e279b96459ab2efe6dd423d81d8
Source dataset
uspto-grants-2004_10
Patent number
US06800629B2

Reaction notes

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