Ammonia → HCID 22662859, compound

HRID 392355Notes

Reaction equation

HRID 392355 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([O:11]C)=O)=[N:4][C:5]([F:8])=[CH:6][N:7]=1.[NH3:13]>CO>[NH2:1][C:2]1[C:3]([C:9]([NH2:13])=[O:11])=[N:4][C:5]([F:8])=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22662844Methyl 3-amino-6-fluoropyrazine-2-carboxylate

Product 1

HCID 22662859HCID 22662859, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 1 mL of methanol was dissolved 10 mg of methyl 3-amino-6-fluoro-2-pyrazinecarboxylate. After adding 1 mL of 25% aqueous ammonia at room temperature, the mixture thus formed was stirred for 4.5 hours. After removing the solvent under reduced pressure, diethyl ether was added to the residue, and the deposited precipitate was filtered off. Thus, 4 mg of 3-amino-6-fluoro-2-pyrazinecarboxamide was obtained as a light yellow-colored solid product.

Workup

  1. customthe mixture thus formed
  2. customAfter removing the solvent under reduced pressure, diethyl ether
  3. additionwas added to the residue
  4. filtrationthe deposited precipitate was filtered off

Sources & evidence

ORD record
ord-641daaddad9d4e32892fd8aed6d5119b
Source dataset
uspto-grants-2004_10
Patent number
US06800629B2

Reaction notes

Loading…