2,2,2-Trifluoroethanesulfonyl chloride → HCID 10224032, compound

HRID 392407Notes

Reaction equation

HRID 392407 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:22][C:23]([F:30])([F:29])[CH2:24][S:25](Cl)(=[O:27])=[O:26]>>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([N:14]([CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[S:25]([CH2:24][C:23]([F:30])([F:29])[F:22])(=[O:27])=[O:26])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 742422,2,2-Trifluoroethanesulfonyl chlorideHCID 4712132HCID 4712132, compound

Product 1

HCID 10224032HCID 10224032, compound

Procedure

Using the method of Example 343 using N-(4-phenoxypheny)pyridin-3-ylmethylamine and 2,2,2-trifluoroethanesulfonyl chloride (Aldrich) and purifying via preparative HPLC eluting with 90:10 to 70:30 DCM/ethyl acetate gave the title compound. Anal Calcd for C20H17F3N2O3S: C, 56.87; H, 4.06; N, 6.63. Found: C, 56.76; H, 4.09; N, 6.69. MS found 423.1 [M+H]+

Workup

  1. custompurifying via preparative HPLC
  2. washeluting with 90:10 to 70:30 DCM/ethyl acetate

Sources & evidence

ORD record
ord-ff88a9c04fe84e4ba752b86e5f80b060
Source dataset
uspto-grants-2004_10
Patent number
US06800651B2

Reaction notes

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