反应详情

Using the method of Example 342 using N-(4-(2,4-difluorophenoxy)phenyl)-1-pyrid-3-ylethylamine and 2,2,2-trifluoroethanesulfonyl chloride and purifying via radial chromatography eluting with 95:5 to 85:15 CHCl3/ethyl acetate gave the title compound. Anal Calcd for C21H17F5N2O3S.0.2H2O: C, 52.98; H, 3.68; N, 5.89. Found: C, 52.88; H, 3.73; N, 5.67. MS found 473.1 [M+H]+

1. custompurifying via radial chromatography
2. washeluting with 95:5 to 85:15 CHCl3/ethyl acetate