2,2,2-Trifluoroethanesulfonyl chloride → HCID 23521654, compound

HRID 392423Notes

Reaction equation

HRID 392423 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:8]=[CH:9][CH:10]=1.[F:23][C:24]([F:31])([F:30])[CH2:25][S:26](Cl)(=[O:28])=[O:27]>>[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([N:11]([CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[S:26]([CH2:25][C:24]([F:31])([F:30])[F:23])(=[O:28])=[O:27])[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 742422,2,2-Trifluoroethanesulfonyl chlorideHCID 22663807HCID 22663807, compound

Product 1

HCID 23521654HCID 23521654, compound

Procedure

Using the method of Example 342 using N-(3-(2-methylphenoxy)phenyl)pyridin-3-ylmethylamine and 2,2,2-trifluoroethanesulfonyl chloride and purifying via radial chromatography eluting with 40:60 to 50:50 THF/hexanes gave the title compound. Anal Calcd for C21H19F3N2O3S.0.1H2O: C, 57.55; H, 4.42; N, 6.39. Found: C, 57.28; H, 4.15; N, 6.33. MS found 437.2 [M+H]+

Workup

  1. custompurifying via radial chromatography
  2. washeluting with 40:60 to 50:50 THF/hexanes

Sources & evidence

ORD record
ord-4f56d4d4349f4e4a99f7af7e73106c3c
Source dataset
uspto-grants-2004_10
Patent number
US06800651B2

Reaction notes

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