HCID 44335650, compound → HCID 23521689, compound

Participants

Reaction Steps

To a solution of N-(3-(α-hydroxybenzyl)phenyl)-N-(ethylsulfonyl)pyrid-3-ylmethylamine (0.717 g, 1.87 mmol) in 10 mL DCM was added activated MnO2 (0.489 g, 5.62 mmol). The reaction was gently heated and sonicated for 5 min then stirred overnight. Another portion of MnO2 (0.489 g, 5.62 mmol) was added and it was sonicated and stirred overnight again. The mixture was filtered through Celite and concentrated to give a pure white solid. 1H NMR: 8.52 (dd,J=4.9, 1.5 Hz, 1H), 8.40 (d,J=2.0 Hz, 1H), 7.74-7.66 (m,5H), 7.61 (m,1H), 7.51-7.42 (m,4H), 7.25 (dd,J=7.8, 4.9 Hz, 1H), 4.93 (s,2H), 3.14 (q,J=7.3 Hz, 2H), 1.45 (t,J=7.3 Hz, 3H). MS calcd. 380.1; MS (M+1) 381.1.

Provenance & Evidence