HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Tetrahydrothienopyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thiopheneethanamine | HCID 116521 | — |
| Product | Tetrahydrothienopyridine hydrochloride | HCID 68420022 | — |
Reaction Steps
2-thienylethlamine was reacted with formaldehyde to give the corresponding formimine, which was then added to a solution of hydrochloric acid in DMF, resulting in cyclization to tetrahydrothienopyridine hydrochloride. The DMF used was anhydrous, KF≦0.05%, to avoid formimine hydrolysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06800759B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-edc66215e27f4952902824878d705b61 |
| Source note | uspto-grants-2004_10 |