HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 12988790, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 12988789 | HCID 12988789 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12988790 | HCID 12988790 | — |
Reaction Steps
2-[(Ethoxycarbonyl)methyl]benzimidazole-5-carboxylic acid (1.0 eq) was dissolved in THF. HBTU (1.1 eq) and diisopropylethylamine (2.0 eq) were added, followed by dimethylamine (2.0 M in THF, 1.1 eq). The reaction was stirred at room temperature overnight then concentrated and the resulting residue was purified by silica gel chromatography (5:95 MeOH:CH2Cl2) to afford the desired compound. LC/MS m/z 276.2 (MH+), Rf 1.18 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06800760B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-ca71003b9ac14c9bad6e37d439dcf8c1 |
| Source note | uspto-grants-2004_10 |