Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 392647생성일: 2026년 10월 25일
Sodium borohydride → N-(3,5-Dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxyindol-3-yl]-2-hydroxyacetamide
https://huagongshe.com/reaction/392647
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | Awd 12-281 | HCID 6918428 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | N-(3,5-Dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxyindol-3-yl]-2-hydroxyacetamide | HCID 9955884 | — |
반응 단계
1 g of N-(3,5-dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxyindol-3-yl]-2-oxoacetamide (1; 2 mmol) are suspended in 75 ml methanol. After addition of a solution of 0.2 g of sodium borohydride in 3 ml dilute sodium hydroxide solution, the reaction mixture is stirred at 20° C. for 6 hours. After the solvent has been removed by distillation, the residue is recrystallized from 40 ml ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | USRE038624E1 |
|---|
| 출처 데이터셋 | uspto-grants-2004_10 |
|---|
| ORD ID | ord-3d8759d969a7437eae07190ed5844658 |
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| 출처 메모 | uspto-grants-2004_10 |
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