Formaldehyde → N-hydroxymethyl-4-chloro-3-methylpyrazole

HRID 392651Notes

Reaction equation

HRID 392651 reaction equation
[Cl:1][C:2]1[C:3]([CH3:7])=[N:4][NH:5][CH:6]=1.[CH2:8]=[O:9]>CO>[OH:9][CH2:8][N:5]1[CH:6]=[C:2]([Cl:1])[C:3]([CH3:7])=[N:4]1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178434543HCID 178434543, compound

Product 1

HCID 11423670N-hydroxymethyl-4-chloro-3-methylpyrazoleYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

116 g (1.0 mol) of 4-chloro-3-methylpyrazole in 50 ml of methanol were dissolved in 100 g (1.0 mol) of formalin solution (30%) at room temperature. Water and methanol were then evaporated. The title compound remained as a white solid (yield 95%).

Workup

  1. customWater and methanol were then evaporated

Sources & evidence

ORD record
ord-9b4c413911fd4434a6bcb5c34e3088b1
Source dataset
uspto-grants-2004_10
Patent number
US06802882B2

Reaction notes

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