関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Sulfate | HCID 24436 | — |
| 反応物 | 1-tert-butyl 3-methyl (3S)-piperazine-1,3-dicarboxylate | HCID 1501855 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate | HCID 24820294 | — |
反応手順
A solution of Example 1 (c) in dry tetrahydrofuran (40 ml) at 0° C. was treated with lithium aluminum hydride (0.50 g) and the mixture was stirred at 0° C. for 1.5 hours. The cooled solution was treated dropwise with a solution of 2M sodium hydroxide until a white precipitate had formed. Dichloromethane and anhydrous sodium sulfate were added and the solution was filtered and evaporated to give a pale yellow oil (3.0 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06803369B1 |
|---|
| 出典データセット | uspto-grants-2004_10 |
|---|
| ORD ID | ord-58b28852f18f4c3bb996c6534bab0abb |
|---|
| 出典メモ | uspto-grants-2004_10 |
|---|
