反应详情

MnO2 (2.66 g) was added to a solution of 3-amino-1-(4-benzyloxy-2-fluorophenyl) pyrazoline (3.86 g) in CH2Cl2 (40 mL), and the mixture was stirred at room temperature for 4 hours. The precipitate (MnO2) was filtered off, and the filtrate was concentrated. The residue was purified by flash chromatography on silica gel (EtOAc/hexane 1/9, 1/4, 1/2 and 1/1) and crystallization from EtOAc/hexane to yield 1.04 g of the title compound.

1. filtrationThe precipitate (MnO2) was filtered off
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by flash chromatography on silica gel (EtOAc/hexane 1/9, 1/4, 1/2 and 1/1) and crystallization from EtOAc/hexane