HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-(4-Fluorobenzyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-Fluorobenzyl)acetamide | HCID 3532104 | 55.2% |
Reaction Steps
4-Fluorobenzylamine (11.4 g, 91 mmol) was dissolved in 910 mL of CH2Cl2. To this was added 910 mL of satd NaHCO3 followed by acetyl chloride (23.4 mL, 329 mmol) stir 1 h. The organic layer was separated, washed with satd NaCl, dried over Na2SO4, filtered and solvent removed to yield 8.4 grams of N-(4-fluoro-benzyl)-acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06803378B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-8cb01639963c4ecd89b7ea6016239016 |
| Source note | uspto-grants-2004_10 |